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Mayo Clinic College of Medicine Professor, Biochemistry and Molecular Biology, and Biomedical Engineering Debabrata Mukhopadhyay, Ph.D. |
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Speech Summary: The use of nanotechnology in biology has grown over recent years, incorporating the use of reagents such as nanoparticles to directly deliver bioconjugates or nanoparticles that can be utilized as biomolecules as well. Our research suggests that gold nanoparticles are antiangiogenic molecules, whereas some of the lanthanide nanorods are proangiogenic. Overall, our goal is to develop the next generation of nanomedicines that can be translated to the clinics in the near future. |
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BIOIDENT Technologies, Inc. CEO Dr. Wasiq Bokhari |
Speech Title: "The Impact of printed electronics for the Life Science market" |
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Short overview printed Electronics and BIOIDENT Potential Applications in Life Sciences Advantages of using printed electronics for
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Bio: Extensive entrepreneurial experience in adoption and commercialization of emerging materials and nanotechnology. At one time worked with Chevron team that built and grew Molecular Diamond Technologies, a new nanomaterials focused business unit. While with Hitachi worked in the areas of emerging electronics, energy and life sciences applications. At MIT was part of team that discovered a fundamental particle called the top quark at the Fermi National Accelerator Laboratory in 1995. Co-founder and Steering Committee Chair of MIT Stanford UC Berkeley Nanotechnology Forum, and worked with PCAST (Presidential Council of Advisors on Science and Technology) on issues related to energy. |
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Ceutical Laboratories Founder Courtland Imel |
Speech Title: "Nanotechnology and Drug Delivery The New Frontier in Medicine" |
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Bio: Founded in 2004, a full-service provider to pharmaceutical, medical device, dietary Supplement, veterinary and cosmetic industries. 25 years experience in FDARegulated industries. Innovator of client product concept, quality control, training,IT solutions, sales and marketing. |
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HemoBioTech, Inc. CoFounder; President and CEO Dr. Arthur P. Bollon |
Speech Title: "HemoTech: Human Blood Substitute" |
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Speech Summary: HemoBioTech, Inc. is developing HemoTech, which could be the first viable substitute for human blood. HemoTech addresses a potential $25 billion market with a revolutionary patented technology. Chairman and CEO, Arthur P. Bollon, Ph.D., will present the properties and potential uses of HemoTech. www.hemobiotech.com. |
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Bio: Scientist, executive, and entrepreneur, with over 25 years experience in biotechnology. Co-Founder of HemoBioTech, developing potentially the first viable substitute for human blood. Also co-Founded Biogress (a biotech service company) and Cytoclonal Pharmaceutics, raising some $65 million, then implementing a licensing agreement with Bristol-Myers Squibb and acquiring Nobel Prize technology for computer based drug design. The author of more than 50 scientific communications. Also served as Editor of the CRC Press Publication "Recombinant DNA Products: Insulin, Interferon and Growth Hormone." At one time Director of Genetic Engineering at Wadley Cancer Center and Assistant Professor, University of Texas Southwestern Medical School, Dallas. |
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ISO-TEX DIAGNOSTICS President Thomas J. Maloney |
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Bio: Pioneer in Nantopes shown to be a highly effective treatment for Carcinoid cancers. Licensed radiopharmaceutical manufacturer of diagnostic, therapeutic and aseptic drugs for terminal cancer patients. Three NDA approved products with four more in Phase 1,2 and 3. While at Union Carbide, produced quantities of radio chemicals and radio pharmaceuticals. |
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Texas Scottish Rite Hospital for Children, Regenerative Neurobiology, Seay Research Center Director Dr. Mario Romero-Ortega |
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Bio: Evaluation of carbon nanotubes sheets as conductive substrates for cellular growth. Also focused on methods to direct nerve regeneration in the peripheral nervous system and spinal cord. Currently leads a team developing biosynthetic nerve prosthesis grafts for peripheral nerve gap repair. Also working towards fully functional bi-directional, sensory/motor peripheral neuro-electrical interfaces. Helped define the molecular mechanisms that guide development of nerve circuits in the spinal cord and possible genetic cause of rare human condition, congenital mirror movement disorder. Also assistant Professor of Neurology and Biomedical Engineering at the University of Texas Southwestern Medical Center, in Dallas. |
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Nanomix, Inc. President & Chief Executive Officer David L. Macdonald |
Speech Title: "The Sensation™ Nanoelectronic Detection Platform Current Developments and Practical Applications " |
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Speech Summary: The Sensation nanoelectronic detection platform provides healthcare providers quick access to critical diagnostic and monitoring information. In respiratory gas detection applications, it reaches those currently underserved by traditional patient monitoring and offers significant advantages over existing solutions. It also simplifies and expands the use of biomolecule analysis, with potential applications in DNA, protein, and glucose detection, through easy-to-use Point-of-Care product configurations. |
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Bio: This detection platform provides healthcare providers quick access to critical diagnostic and monitoring information. In respiratory gas detection applications, it reaches those currently underserved by traditional patient monitoring and offers significant advantages over existing solutions. It also simplifies and expands the use of biomolecule analysis, with potential applications in DNA, protein, and glucose detection, through easy-to-use Point-of-Care product configurations. |
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NanoViricides, Inc. Chief Executive Officer Eugene Seymour, MD, MPH |
Speech Title: "The use of a novel nanoviricide in the treatment of viral infections" |
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Speech Summary: Since the discovery of vaccination by Edward Jenner at the end of 18th century, there has been little progress made in treating the various viral diseases that affect both animals and humans. Although extensive progress has been made against certain viral diseases, notably HIV and Hepatitis C, no anti-viral therapeutics existed that actually destroyed the virus. Utilizing the principles of nanotechnology, we have been able to create a broad-spectrum anti-viral therapeutic platform that actually results in viral destruction. The science of the technology and its implications for human and animal health will be discussed. |
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Bio: Co-founder of this bio-pharmaceutical startup devoted to treatment of viral diseases. Trained as a chemist; attended medical school and has practiced medicine for over thirty years. Holder of 8 issued patents. Served as a medical officer in the U.S. Army during the Vietnam era. |
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University of Missouri Professor of Chemistry Dr. J. David Robertson |
Speech Title: "Neutron Activation Analysis of the Biodistribution and Tissue Uptake of Gadolinium, Gold, and Silver Nanoparticles"> |
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Speech Summary: A critical step in the development and application of nanoparticles for medicine and consumer products is an understanding of the uptake and biodistribution of the nanoparticles. In small animal models traditional analytical techniques are challenged by small samples sizes and low concentrations. This paper outlines the use of neutron activation analysis as a powerful technique for examining uptake and biodistribution of gadolinium, gold and silver nanoparticles. |
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Bio: Research interests focused on developing radionuclear methods of analysis and its application to fundamental areas including Alzheimer disease, nanoscience and potential health impacts of fine airborne particulate. Many published research articles in U.S. and Canada. Expert in analytical chemistry. |
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ONAMI-SNNI (Safer Nanomaterials and Nanomanufacturing Initiative) Assistant Director Dr. Joanne I. Yeh |
Speech Title: "Coordinated Nanobiosensors for Enhanced Detection: Integration of Three Dimensional Structures with Nanoelectrode Platforms" |
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Speech Summary: The ability to monitor biorecognition events and interactions on platforms offers pathways to the application of biological macromolecules as detectors. Coupled to the ability to precisely produce conductive elements on the nanoscale, biosensing offers unprecedented avenues for screening and detection at increasing sensitivities. A nanobiosensor, in our applications, consists of a biological molecule, linker or mediator, and nanoelectrodes. The various components can be equated with the electronic elements of a sensor as every module has to transduce the signals generated at the source (biomolecule) to the detector (electrode). Consequently, as in enzyme systems, rate improvements can occur from proximity and geometric effects, with potential enhancements of 102 to 103 at each junction. The additive consequence can be a gain of several orders of magnitude in rates with concomitant improvement in sensitivities. We have produced nanobiosensors using the redox enzymes, conductive biolinkers, immobilized onto nanoelectrode platforms. These integrated sensors detected multiple biomarkers at high sensitivities, demonstrating the feasibility of these as responsive detectors of biological signals. Our results indicate the potential applications of utilizing nanomaterials in targeted cellular treatments and nanobiosensors in medical diagnostics to identify "pro-disease" states. |
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Bio: Many published papers in the field of nanotechnology, biophysics , chemical carcinogensis and biomaterials. Extensive studies on soluble and membrane proteins in oxidative and glycerol metabolism pathways. |
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Ohio University Physics and Astronomy Dr. Ido Braslavsky |
Speech Title: "Ice binding proteins, their interaction with ice surfaces and their applications" |
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Speech Summary: Ice binding proteins are found in cold climate organisms such as fish, insects, and plants. These proteins stop these organisms from freezing by binding to ice crystals through specific affinity to particular surfaces. Ice binding proteins have many potential applications in areas such as cryomedicine, cryopreservation. Moreover, they could potentially serve as a platform for future nanotechnology applications in which crystal growth is controlled by specific additives. We have developed novel tools to investigate ice binding proteins operation, including fluorescence microscopy and microfluidic devices. A direct visualization of proteins on ice crystals shed light on the ways these protein operate. |
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Bio: Biophysicist, BA and PhD at Technion Hafia, Postdoc at Weizmann institute of Science and at California Institute of Technology. Involved in the development of single molecule DNA sequencing while at Caltech. Consulted to Helicos Biosciences which form to develop and commercialize the innovative sequencing platform. Expert in antifreeze proteins and pioneer in the development of fluorescence techniques and microfluidics devices to investigate them. Member of NQPI - Nanoscale & Quantum Phenomena Institute and of QBI – Quantitative Biology Institute. |
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Center for Commercialization of Fluorescent Technologies (CCFT) Dr. Zygmunt (Karol) Gryczynski |
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Bio: Currently focused to explore quantum-level interactions to study dynamics of biophysical and biochemical processes at the molecular level. Pioneer in the use of multi-photon excitation and light quenching in time-resolved fluorescence spectroscopy, as well as fluorescence sensing methods for biomedical applications in tissue and blood. Interests expanded to nanotechnology and applications of plasmonic effects induced by light in metallic nanostructures. |
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Department of Molecular Biology and Immunology University of North Texas Health Science Center Chief Scientist - Center for Nano and Molecular Science Andras G. Lacko, Ph.D. |
Speech Title: "Novel Biocompatible Nanoparticles for Targeted Cancer Therapy" |
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Speech Summary: Lipoproteins are considered to be appropriate drug delivery agents, especially for cancer chemotherapy. Our laboratory has developed a highly effective drug delivery platform, using ingredients of high density lipoproteins. These developments open the way for dramatic improvements in innovative drug delivery technology. Synthetic high density lipoprotein nanoparticles, carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier (Anticancer Research 22(4):2045-9[2002]). The rHDL/PTX complexes appeared to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability by both ultracentrifugation and column chromatography. The rHDL/ PTX nanoparticles had superior cytotoxicity against several cancer cell lines with an IC50 5-20 times lower than that of the free drug. Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol® or Abraxane® |
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Bio: Research has involved the structure/function and metabolism of plasma lipoproteins, key components of cholesterol transport. Since 1998, research has been focused on using synthetic lipoproteins as drug carriers, particularly for cancer chemotherapy. Has published over 100 articles and has given numerous presentations at international meetings and Academic institutions around the world. Has organized four international meetings on high density lipoproteins and reverse cholesterol transport. |
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University of North Texas Health Science Center Bioengineer Dr. Art Braden |
Speech Title: "Developing targeted nano-therapies: From ocular delivery to prostate cancer." |
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Speech Summary: This presentation will present preliminary data on the use of poly lactic-co-glycolic acid based nanoparticles as potential clinical treatment options. Initial information will be provided showing nanoparticle accumulation in the retina and targeted delivery to retinal ganglion cells. The following portion of the presentation will be on the ability of plasmid DNA encapsulating nanoparticles to serve as effective mediators of prostate cancer progression. The final portion of the presentation will drive toward the formulation of an antibody targeted nanoparticle for prostate cancer treatment. |
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Bio: Bioengineer specializing in drug delivery from polymeric nanoparticles and bioconjugate chemistry. Currently focusing on the develppment of nano-therapeutics for various diseases such as cancer, glaucoma and COPD. |
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The University of Texas at Dallas Paul Pantano, Ph.D. |
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Speech Summary: "Characterizing Single-Walled Carbon Nanotube (SWNT) Production Lots and Measuring the Uptake of Purified SWNTs by Living Cells." |
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Bio: In the field of nanomedicine, a key question is whether reports of carbon nanotube (CNT) cytotoxicity are due to the CNTs themselves or to impurities in CNT-containing powders. Regrettably, reports continue to be published without thorough material characterizations of CNT-containing powders for the presence of metal and non-tubular carbon impurities. Recently, we have demonstrated that purified, protein-coated HiPco or CoMoCAT single-walled CNTs (SWNTs) are taken-up by HeLa cells and NRK cells without affecting morphologies and growth rates – evidence that SWNTs inside cells are not toxic under these conditions. This presentation will emphasize the importance of thoroughly characterizing CNT materials before cytotoxicity assessments are offered, and will present our most recent research concerning the direct, label-free measurement and imaging of SWNTs in living cells and tissue. |
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University of Texas, Southwestern Department of Urology Dr Joshua Stern |
Speech Title: "Selective Prostate Cancer Thermal Ablation with Laser Activated Gold Nanoshells." |
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Speech Summary: As a urologic surgeon the bedrock of our training has historically been one of extirpative surgery; that is, if a cancer is found, remove it. With advancing technology however, a movement towards minimally invasive in situ surgery has begun. Thermal ablative technologies have taken hold in the treatment of renal cancers. It is anticipated that the treatment of prostate cancer will follow suit. We will discuss the available nanotechnology developments in the thermal ablation of prostate cancer utilizing laser activated gold nanoshells. |
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Bio: Nanotechnology research focusses on developing thermal ablative technologies for the treatment of urologic disease. Chief Urologic Resident in Department of Urology at UTSW Medical Center Recipient of fellowships from the American Federation for Aging Research and the Cornell Molecular Biology department. Undergraduate degree, University of Pennsylvania; Medical degree, Weill Cornell Medical College. |
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